スポンサーサイト

上記の広告は1ヶ月以上更新のないブログに表示されています。
新しい記事を書く事で広告が消せます。

論文要旨(エクジソン)

Phytochemistry
Volume 57, Issue 3, June 2001, Pages 401-407
Ecdysteroids and bufadienolides from Helleborus torquatus (Ranunculaceae)
Yanhui Meng a, 1, Pensri Whiting a, Vladimir Imageik b, Huw H. Rees c and Laurence Dinan a
a Department of Biological Sciences, University of Exeter, Hatherly Laboratories, Prince of Wales Road, Exeter, Devon, EX4 4PS, UK
b Department of Chemistry, University of Exeter, Stocker Road, Exeter, Devon, EX4 4QD, UK
c School of Biological Sciences, University of Liverpool, Life Sciences Building, Crown Street, Liverpool, L69 7ZB, UK

Abstract
Three bufadienolides, hellebortin A (5-[β-Image-glucopyranosyloxy]-10,14,16-trihydroxy-19-nor-{5β,10β,14β,16β}-bufa-3,20,22-trienolide [1]), hellebortin B (5-[β-Image-glucopyranosyloxy]-3,4-epoxy-14-hydroxy-19-oxo-bufa-20,22-dienolide [2]) and hellebortin C (5-[β-Image-glucopyranosyloxy]-3,4-epoxy-10,14-dihydroxy-19-nor-bufa-20,22-dienolide [3]), together with 20-hydroxyecdysone 3-O-β-Image-glucoside (4) and 20-hydroxyecdysone (5) have been isolated by bioassay- and RIA-directed HPLC analyses of a methanol extract of the seeds of Helleborus torquatus. The structure and relative stereochemistry of the novel bufadienolide hellebortin A (1) and the structures of hellebortin B (2) and hellebortin C (3) were determined unambiguously by comprehensive analyses of their 1D and 2D NMR data. These five compounds are isolated from Helleborus torquatus for the first time. The biological activities of compound 1, 4 and 5 as ecdysteroid agonists and antagonists have been assessed.


Biochemical Systematics and Ecology
Volume 30, Issue 2, February 2002, Pages 171-182
Chemotaxonomic significance of ecdysteroid agonists and antagonists in the Ranunculaceae: phytoecdysteroids in the genera Helleborus and Hepatica
Laurence Dinan, Tamara Savchenko and Pensri Whiting
Hatherly Laboratories, Department of Biological Sciences, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK

Abstract
We present here a survey of ca. 100 species within 16 genera of the family Ranunculaceae for the presence of ecdysteroid agonist and antagonist activities in methanolic seed extracts. The levels of phytoecdysteroids (agonists) have been quantified by radioimmunoassay and bioassay. A few samples possess weak antagonistic activity. Phytoecdysteroids are most prominently associated with the genus Helleborus. In this genus, species fall into two distinct classes: those with low or undetectable ecdysteroid levels and those with high ecdysteroid levels. The relationship between ecdysteroid levels and the biology of the plants in this genus is discussed. Additionally, the extract of Hepatica triloba Chaix seeds contains a significant level of phytoecdysteroids. Several other species contain low levels of phytoecdysteroids, as detected by radioimmunoassay. Together with our previous data on the genera Anemone and Pulsatilla, this survey allows us to present an overview of the distribution of ecdysteroids in this family.
スポンサーサイト

テーマ : ☆クリスマスローズ☆
ジャンル : 趣味・実用

コメントの投稿

非公開コメント

sidetitleプロフィールsidetitle

conocono

Author:conocono
花好きおじさんの園芸と植物に関するあれこれ。
たまに作り話もあるので要注意。

sidetitle最近の記事sidetitle
sidetitleカテゴリーsidetitle
sidetitle月別アーカイブsidetitle
sidetitleメールフォームsidetitle

名前:
メール:
件名:
本文:

sidetitleFC2カウンターsidetitle
sidetitleブログ内検索sidetitle
sidetitleリンクsidetitle
sidetitleRSSフィードsidetitle
上記広告は1ヶ月以上更新のないブログに表示されています。新しい記事を書くことで広告を消せます。